We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Immunosuppressive ent-Kaurene Diterpenoids from Isodon serra.
- Authors
Ai-Hua Zhao; Yan Zhang; Zhao-Hui Xu; Jian-Wen Liu; Wei Jia
- Abstract
Three new enmein-type ent-kaurenoids, i.e., the two pairs 1 and 2 of 20-epimers and the (20R)-isomer 3, besides the seven known diterpenoids 410, were isolated from the aerial parts of Isodon serra. Their structures were elucidated by spectroscopic techniques and X-ray diffraction. The immunosuppressive effect for T-lymphocytes proliferation induced by Con 4;A in BALB/c mouse was evaluated for the isolates 110. They all displayed a remarkable inhibitory effect, with multi-glycosides of Tripterygium wilfordii as positive reference substance (Table 4;3).
- Subjects
IMMUNOSUPPRESSIVE agents; IMMUNOPHARMACOLOGY; LEUCOCYTES; GLYCOSIDES
- Publication
Helvetica Chimica Acta, 2004, Vol 87, Issue 12, p3160
- ISSN
0018-019X
- Publication type
Article