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- Title
Synthesis of Novel Pyrimidine Derivatives Containing the Vinylsulfanyl Group by Regio- and Stereoselective Addition of Thiouracils to Ethynyl Ketones.
- Authors
Amosova, Svetlana V.; Yaroshenko, Tatyana I.; Larina, Lyudmila I.; Timokhina, Lyudmila V.; Potapov, Vladimir A.
- Abstract
ABSTRACT A regio- and stereoselective method for preparation of novel functionalized pyrimidine derivatives containing the vinylsulfanyl group has been developed based on addition reactions of 2-thiouracils with phenylethynyl ketones. Reactions with ketones containing the disubstituted triple bond afford adducts of Z-stereochemistry, whereas addition to ketone with the terminal triple bond gives preferentially products of E-configuration.
- Subjects
CHEMICAL synthesis; PYRIMIDINES; KETONES; TRIPLE bonds (Chemistry); CHEMICAL adducts
- Publication
Heteroatom Chemistry, 2015, Vol 26, Issue 3, p187
- ISSN
1042-7163
- Publication type
Article
- DOI
10.1002/hc.21247