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- Title
N,N-dimethylformamide-promoted reaction of isocyanides and barbituric acids: an easy synthesis of 5-[(alkyl or arylamino)methylene]barbituric acids.
- Authors
Teimouri, Mohammad Bagher; Tayyebi, Ahmad
- Abstract
N,N-dimethylformamide promoted the reaction of alkyl or arylisocyanides with barbituric acid derivatives which led to 5-[(alkyl or arylamino)methylene]barbituric acids in good yields at room temperature. The work-up of reactions was very simple and the crude products were sufficiently pure to be used without further purification. This procedure provides an alternative method for the synthesis of aminomethylenebarbituric acids.
- Subjects
ORGANIC synthesis; DIMETHYLFORMAMIDE; ISOCYANIDES; ACIDS; CARBENES; PHYSIOLOGICAL effects of hydrocarbons; CHEMICAL reactions; TEMPERATURE effect; CATALYSIS
- Publication
Journal of Chemical Research, 2010, Vol 34, Issue 3, p140
- ISSN
1747-5198
- Publication type
Article
- DOI
10.3184/030823410X12682371167951