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- Title
Clinical utility of FDG-PET for the differential diagnosis among the main forms of dementia.
- Authors
Nestor, Peter J.; Altomare, Daniele; Festari, Cristina; Drzezga, Alexander; Rivolta, Jasmine; Walker, Zuzana; Bouwman, Femke; Orini, Stefania; Law, Ian; Agosta, Federica; Arbizu, Javier; Boccardi, Marina; Nobili, Flavio; Frisoni, Giovanni Battista; for the EANM-EAN Task Force for the Prescription of FDG-PET for Dementing Neurodegenerative Disorders
- Abstract
Aim: To assess the clinical utility of FDG-PET as a diagnostic aid for differentiating Alzheimer’s disease (AD; both typical and atypical forms), dementia with Lewy bodies (DLB), frontotemporal lobar degeneration (FTLD), vascular dementia (VaD) and non-degenerative pseudodementia.Methods: A comprehensive literature search was conducted using the PICO model to extract evidence from relevant studies. An expert panel then voted on six different diagnostic scenarios using the Delphi method.Results: The level of empirical study evidence for the use of FDG-PET was considered good for the discrimination of DLB and AD; fair for discriminating FTLD from AD; poor for atypical AD; and lacking for discriminating DLB from FTLD, AD from VaD, and for pseudodementia. Delphi voting led to consensus in all scenarios within two iterations. Panellists supported the use of FDG-PET for all PICOs—including those where study evidence was poor or lacking—based on its negative predictive value and on the assistance it provides when typical patterns of hypometabolism for a given diagnosis are observed.Conclusion: Although there is an overall lack of evidence on which to base strong recommendations, it was generally concluded that FDG-PET has a diagnostic role in all scenarios. Prospective studies targeting diagnostically uncertain patients for assessing the added value of FDG-PET would be highly desirable.
- Subjects
ALZHEIMER'S disease diagnosis; DIAGNOSIS of dementia; FLUORODEOXYGLUCOSE F18; POSITRON emission tomography; LEWY body dementia; FRONTOTEMPORAL lobar degeneration; FACTITIOUS disorders; VASCULAR dementia
- Publication
European Journal of Nuclear Medicine & Molecular Imaging, 2018, Vol 45, Issue 9, p1509
- ISSN
1619-7070
- Publication type
Article
- DOI
10.1007/s00259-018-4035-y