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- Title
Journey from Serendipity to Biologics.
- Authors
Rao, Nutan; Kini, Riddhi; Maniyar, Drashti; Amin, Rishika
- Abstract
The world today is largely focused on biologics-based treatment for many diseases as it is a very specific way to treat any disease and also happens to have the least side effects compared to conventional medicine system. Biologics are generally huge molecules derived from living cells and used in the treatment, diagnosis, or prevention of diseases. Biologic medicines include therapeutic proteins, DNA vaccines, monoclonal antibodies, and fusion proteins. The aim of this review is to learn how biologics came into existence and how beneficial they are to the mankind as compared to the traditional medicines. This study also helps to understand how biologics are useful as safe alternative in treatment of some major diseases like Rheumatoid Arthritis, Crohn's disease and Psoriasis. It sheds light on the chronology which led to the development of biologics starting from the natural product era to their current status. Some biologics are desperately awaited for treatment of diseases so as to either reduce the number of side effects or as totally new drugs against some orphan diseases. These drugs include gene therapy products, biosimilars, oncolytic virus therapy, etc. Although biologics are mainly associated with immune reactions, optimum modifications will definitely serve the purpose of getting agents acting on specific targets. Biologics seem to have the potential to rule the pharmaceutical industry and market.
- Subjects
MONOCLONAL antibodies; ONCOLYTIC virotherapy; CROHN'S disease; BIOLOGICALS; SERENDIPITY in science; CHIMERIC proteins
- Publication
Pharmaceutical Chemistry Journal, 2022, Vol 55, Issue 12, p1329
- ISSN
0091-150X
- Publication type
Article
- DOI
10.1007/s11094-022-02579-1