We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Synthesis and hemostatic and antimicrobial activities of the sodium salts of N-acyl-5-bromo(3,5-dibromo)anthranilic acids.
- Authors
Andryukov, K.; Ismailova, N.; Tomilov, M.; Korkodinova, L.; Syropyatov, B.; Odegova, T.; Vakhrin, M.; Kozhevnikov, Yu.
- Abstract
ylation of 5-bromo(3,5-dibromo)anthranilic acids with the corresponding anhydrides yielded 10 N-acyl-5-bromo(3,5-dibromo)anthranilic acids. The resulting compounds were reacted with 10% sodium hydroxide to convert them to the corresponding sodium salts. The hemostatic and antimicrobial activities against Staphylococcus aureus and Escherichia coli of the resulting compounds were studied. Compound IV, containing a phenyl residue in the acyl fragment, was found to have marked hemostatic activity (18.2%) and weak antimicrobial activity. The minimum inhibitory concentration for this compound was 500 μg/ml against S. aureus and E. coli. The other sodium salts were significantly less active.
- Subjects
ANTI-infective agents; ALKALI metals; SODIUM salts; ANHYDRIDES; STAPHYLOCOCCUS aureus; ESCHERICHIA coli; ORGANIC synthesis
- Publication
Pharmaceutical Chemistry Journal, 2011, Vol 45, Issue 1, p12
- ISSN
0091-150X
- Publication type
Article
- DOI
10.1007/s11094-011-0550-x