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- Title
Analyzing marginal cases in differential shotgun proteomics.
- Authors
Carvalho, Paulo C.; Fischer, Juliana S. G.; Perales, Jonas; Yates, John R.; Barbosa, Valmir C.; Bareinboim, Elias
- Abstract
Summary: We present an approach to statistically pinpoint differentially expressed proteins that have quantitation values near the quantitation threshold and are not identified in all replicates (marginal cases). Our method uses a Bayesian strategy to combine parametric statistics with an empirical distribution built from the reproducibility quality of the technical replicates.Availability:The software is freely available for academic use at http://pcarvalho.com/patternlab.Contact: paulo@pcarvalho.comSupplementary information: Supplementary data are available at Bioinformatics online.
- Subjects
PROTEIN analysis; PROTEOMICS; GENE expression; EMPIRICAL research; COMPUTER software; SCIENCE publishing; BIOINFORMATICS
- Publication
Bioinformatics, 2011, Vol 27, Issue 2, p275
- ISSN
1367-4803
- Publication type
Article
- DOI
10.1093/bioinformatics/btq632