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- Title
MSX-3D: a tool to validate 3D protein models using mass spectrometry.
- Authors
Michaël Heymann; David Paramelle; Gilles Subra; Eric Forest; Jean Martinez; Christophe Geourjon; Gilbert Deléage
- Abstract
Motivation: The technique of chemical cross-linking followed by mass spectrometry has proven to bring valuable information about the protein structure and interactions between proteic subunits. It is an effective and efficient way to experimentally investigate some aspects of a protein structure when NMR and X-ray crystallography data are lacking. Results: We introduce MSX-3D, a tool specifically geared to validate protein models using mass spectrometry. In addition to classical peptides identifications, it allows an interactive 3D visualization of the distance constraints derived from a cross-linking experiment. Availability: Freely available at http://proteomics-pbil.ibcp.fr Contact: g.deleage@ibcp.fr
- Subjects
BIOINFORMATICS; PROTEIN structure; PROTEIN crosslinking; MOLECULAR structure; MASS spectrometry; THREE-dimensional imaging; X-ray crystallography; COMPUTER software
- Publication
Bioinformatics, 2008, Vol 24, Issue 23, p2782
- ISSN
1367-4803
- Publication type
Article
- DOI
10.1093/bioinformatics/btn510