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- Title
Non-target site SDHI resistance is present as standing genetic variation in field populations of Zymoseptoria tritici.
- Authors
Masao Yamashita; Fraaije, Bart
- Abstract
BACKGROUND: A new generation of more active succinate dehydrogenase (Sdh) inhibitors (SDHIs) is currently widely used to control Septoria leaf blotch in northwest Europe. Detailed studies were conducted on Zymoseptoria tritici field isolates with reduced sensitivity to fluopyram and isofetamid; SDHIs which have only just or not been introduced for cereal disease control, respectively. RESULTS: Strong cross-resistance between fluopyram and isofetamid, but not with other SDHIs, was confirmed through sensitivity tests using laboratory mutants and field isolates with and without Sdh mutations. The sensitivity profiles of most field isolates resistant to fluopyram and isofetamid were very similar to a lab mutant carrying SdhC-A84V, but no alterations were found in SdhB, C andD. Inhibition of mitochondrial Sdh enzyme activity and control efficacy in planta for those isolateswas severely impaired by fluopyramand isofetamid, but not by bixafen. Isolates with similar phenotypes were not only detected in northwest Europe but also in New Zealand before the widely use of SDHIs. CONCLUSION: This is the first report of SDHI-specific non-target site resistance in Z. tritici. Monitoring studies show that this resistance mechanism is present and can be selected fromstanding genetic variation in field populations.
- Subjects
SUCCINATE dehydrogenase; BIOLOGICAL variation; SEPTORIA diseases; MYCOSPHAERELLA leaf blotch disease; MICROBIAL sensitivity tests; PHENOTYPES; PREVENTION
- Publication
Pest Management Science, 2018, Vol 74, Issue 3, p672
- ISSN
1526-498X
- Publication type
Article
- DOI
10.1002/ps.4761