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- Title
Effect of American genomic ancestry on severe toxicities in children with acute lymphoblastic leukemia in the Amazon region.
- Authors
Wanderley, Alayde Vieira; de Moraes, Francisco Cezar Aquino; da Costa Nunes, Giovanna Gilioli; Pereira, Esdras Edgar Batista; Leitão, Luciana Pereira Colares; de Oliveira, Marcelo Braga; Tavares, Ágatha Tereza Miranda; da Costa Pantoja, Laudreisa; Khayat, Bruna Cláudia Meireles; Fernandes, Marianne Rodrigues; de Assumpção, Paulo Pimentel; dos Santos, Ândrea Kely Ribeiro; Burbano, Rommel Mario Rodríguez; dos Santos, Sidney Emanuel Batista; Ribeiro, Raul; Khayat, André Salim; dos Santos, Ney Pereira Carneiro
- Abstract
Background: Acute Lymphoblastic Leukemia (ALL) is a neoplasm of the hematopoietic system characterized by a clonal expansion of abnormal lymphocyte precursor cells. ALL is the most common form of cancer in children, but despite advances in treatment, it can still be fatal. Ethnic differences influence survival rates, and genomic ancestry plays an important role, especially in mixed-race populations such as Latin America. This study aims to analyze the influence of genomic ancestry on toxicity in children with ALL in the Amazon region. Methods: The study included 171 patients (protocol number 119,649/2012—Ethics Committee) with ALL treated at a pediatric treatment center in Belém do Pará, in the Brazilian Amazon. The patients were submitted to the BFM protocol of induction therapy for ALL. Toxicity was assessed based on laboratory tests and adverse events, classified according to the CTC-NCI guide. Genomic ancestry was determined using autosomal informative markers. Results: The majority of children (94.74%) developed some type of toxicity during treatment, 87.04% of which were severe. Infectious toxicity was the most common, present in 84.8% of cases, 77.24% of which were severe. Amerindian ancestry showed an association with the risk of severe general toxicity and severe infectious toxicity, with a contribution of 35.0% demonstrating a significant increase in risk. In addition, post-induction refractoriness and relapse were also associated with an increased risk of death. Conclusion: This study highlights the influence of Amerindian genomic ancestry on response to therapy and toxicity in children with ALL in the Amazon region. Understanding these associations can contribute to personalizing treatment and improving clinical outcomes.
- Subjects
LYMPHOBLASTIC leukemia; ACUTE leukemia; HEMATOPOIETIC system; GENEALOGY; HEMATOLOGIC malignancies
- Publication
Discover Oncology, 2024, Vol 15, Issue 1, p1
- ISSN
2730-6011
- Publication type
Article
- DOI
10.1007/s12672-024-01014-z