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- Title
气相色谱-三重四极杆质谱法测定染发剂中 14种N-亚硝胺类化合物.
- Authors
张 静; 赖俊敏; 李思源; 严小红; 丁 怡; 张起辉
- Abstract
A gas chromatography-tandem mass spectrometry( GC-MS/MS) method was established for the simultaneous detection of 14 N-nitrosamines( N-nitrosodimethylamine, N-nitrosoethylmethylamine, N-nitrosodiethylamine, N-nitrosoethylisopropylamine, N-nitrosodiisopropylamine, N-nitrosoethylpropylamine, N-nitrosodipropylamine, N-nitrosodibutylamine, N-nitrosomethylaniline, nitrosoethylphenylamin, N-nitrosopiperidine, N-nitrosopyrrolidine, N-nitrosomorpholine, N-nitrosodiphenylamine) in hair dyes. Pretreating based on QuEChERS method, the analytes were separated by polyethylene glycol quartz capillary gas chromatographic column HP-INNOWAX (30 m×0.25 mm×0.25 μm) following the GC temperature program. Mass spectrometric ionization was undertaken in electron impact( EI) ionization mode, and the MS detector was operated in multiple reaction monitoring( MRM) mode including quantitative ion pair and qualitative ion pair for all analytes. The correlation coefficients of the standard calibration curves are greater than 0.998 in the range of 5-100 μg/L. The limits of detection are 0.2-1.5 μg/L, and the limits of quantification are 0.6-5 μg/L, respectively. The average recoveries of 14 N-nitrosamines range from 83.8% to 122.8% at the spiked levels of 25, 50 and 100 μg/kg, with the relative standard deviations( RSDs) less than 11% (n=6). N-nitroso-n-methylaniline is detected at the level of 31 μg/kg in one hair dye sample. The developed method is simple, rapid, exclusive, sensitive, accurate and precise. This method can be applied in the identification and quantitative of 14 N-nitrosamines in hair dyes.
- Subjects
HAIR dyeing &; bleaching; DYES &; dyeing; MASS spectrometry; GASES
- Publication
China Surfactant Detergent & Cosmetics, 2023, Vol 53, Issue 11, p1334
- ISSN
1001-1803
- Publication type
Article
- DOI
10.3969/j.issn.2097-2806.2023.11.013