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- Title
Otoimmün Büllöz Hastalığı Olan Hastalarda Rituksimab'ın Etkinliği: Retrospektif Kohort Çalışması.
- Authors
Aşkın, Özge; Gök, Ayşe Mine; Uzunçakmak, Tuğba Kevser; Kutlubay, Zekayi
- Abstract
Objective: The aim of this study was to evaluate the effectiveness of rituximab in autoimmune bullous diseases. Materials and Methods: In this study, the data of patients who received rituximab treatment for autoimmune bullous disease in our clinic between 2012 and 2019 were retrospectively reviewed. The patients age, sex, diagnosis, presence of cutaneous / mucosal involvement before infusion, number of infusions, antidesmoglein 1, anti-desmoglein 3 and indirect immunofluorescence data before and after treatment, treatment responses and side effects were recorded. Results: In our study, we found a significant decrease in anti-desmoglein 1 and anti-desmoglein 3 levels and accumulations in indirect immunofluorescence after rituximab treatment. (P <0.001 for both) Conclusion: The results from our study showed that rituximab is an effective agent that can be used with systemic steroid treatment.
- Publication
Van Tip Dergisi, 2021, Vol 28, Issue 1, p133
- ISSN
1300-2694
- Publication type
Article
- DOI
10.5505/vtd.2021.35336