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- Title
Liver proliferating cell nuclear antigen, BAX/Bcl-2 ratio, collagen, and polysaccharide accumulation as diagnostic tools in experimental hepatocellular carcinoma.
- Authors
Abdel-Hamid, Nabil Mohie; Hassan, Mohamed K.; Ahmed, Amal A. M.; Allah, Sara Gamal Abd; Anber, Nahla H.
- Abstract
Objectives: This experimental study was conducted to look for a sensitive diagnostic panel for early detection of hepatocellular carcinoma (HCC). Methods: Combination of diethyl nitrosamine (DENA, 200 mg/kg, IP, once), two weeks later, CCl4 (3 ml/kg/week), subcutaneously, for 6 weeks) induced HCC in rats. Sixteen male Wistar rats were divided into 2 groups, control, and HCC. Results: DENA plus CCl4 elevated serum alpha-fetoprotein, liver enzyme activity and depressed superoxide dismutase, reduced glutathione (GSH), elevated malondialdehyde. Also, depressed caspase-3, elevated collagen, polysaccharide accumulation, proliferating cell nuclear antigen in liver tissues, and depressed BAX/Bcl-2 ratio. Conclusion: Decreased BAX/Bcl-2 ratio, elevated collagen deposition, polysaccharide accumulation, nuclear proliferation, and tissue oxidative stress help in the early diagnosis of liver cancer.
- Subjects
PROLIFERATING cell nuclear antigen; POLYSACCHARIDES; HEPATOCELLULAR carcinoma; LIVER cells; COLLAGEN
- Publication
Journal of Contemporary Medical Sciences, 2022, Vol 8, Issue 1, p59
- ISSN
2415-1629
- Publication type
Article
- DOI
10.22317/jcms.v8i1.1162