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- Title
Evaluation of Imidacloprid Induced Changes in Thyroid Gland and its Amelioration with Withania somnifera in Wistar Rats.
- Authors
Samala, Soujanya; Mekala, Lakshman; Doppalapudi, Madhuri; Alla, Gopala Reddy; Rao, Rama
- Abstract
The study was conducted on a total of 48 female Wistar rats divided into four groups, each containing 12 rats. Group 1 was control, group 2 was imidacloprid control, group 3 was Withania somnifera control and group 4 was administered with both imidacloprid and Withania somnifera. The rats of group 3 and 4 were subjected to oral treatment of Withania somnifera (1 gm/kg feed) for a period of 30 days to measure the protective effect against thyroid toxicity induced by imidacloprid (30 mg/kg body weight/day for 30 days). Hormonal assays showed a significant (p<0.05) rise in thyroid stimulating hormone and fall in triidothyronine and thyroxine in imidacloprid administered rats when compared to control. No gross lesions were noticed in thyroid gland. Group 2 thyroid gland sections revealed congestion, degenerated thyroid follicles with loss of colloid substance, increase in inter-follicular space, atropic follicles, fibrosis, pyknotic nuclei, detachment of follicular epithelial cells, increase in number of micro-follicles and proliferation of follicular epithelium towards lumen. Electron microscopy of thyroid gland from group 2 rats revealed significant pathological changes. The degree of lesions was minimal in group 4 rats when compared to group 2 rats. These results indicate that Withania somnifera is beneficial in ameliorating the imidacloprid induced thyroid toxicity in rats.
- Subjects
WITHANIA somnifera; THYROID gland; LABORATORY rats; IMIDACLOPRID; THYROTROPIN
- Publication
Indian Journal of Veterinary Sciences & Biotechnology, 2023, Vol 19, Issue 5, p16
- ISSN
2394-0247
- Publication type
Article
- DOI
10.48165/ijvsbt.19.5.03