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- Title
Synthesis of Substituted Thienopyrimidinones Based on Ethyl 2-Amino-4-(1,4-benzodioxan-2-yl)thiophene-3-carboxylate.
- Authors
Vardanyan, S. O.; Avagyan, A. S.; Sargsyan, A. B.; Harutyunyan, S. A.; Gasparyan, H. V.; Aghekyan, A. A.
- Abstract
Previously synthesized ethyl 2-benzamido-4-(1,4-benzodioxan-2-yl)thiophene-3-carboxylates were cyclized to 2-aryl-3-aminothieno[2,3-d]pyrimidin-4(1H)-ones by the action of hydrazine hydrate. The con-densation of ethyl 2-amino-4-(1,4-benzodioxan-2-yl)thiophene-3-carboxylate with chloroacetyl chloride gave the corresponding N-substituted 2-chloroacetamide which reacted with piperidine and morpholine to produce 2-aminoacetamides, and the latter were also subjected to cyclization with hydrazine hydrate to obtain 3-amino-thienopyrimidin-4-one derivatives. The synthesized compounds were tested for antihypoxic activity.
- Subjects
CHEMICAL synthesis; HYDRAZINE derivatives; HYDRAZINE; PIPERIDINE; MORPHOLINE; HYDRAZINES
- Publication
Russian Journal of Organic Chemistry, 2024, Vol 60, Issue 3, p397
- ISSN
1070-4280
- Publication type
Article
- DOI
10.1134/S1070428024030047