We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Synthesis of 4-(Hydroxymethyl)dihydroisoindolium Salts and Their Intramolecular Recyclization.
- Authors
Chukhadzhyan, Em. O.; Gevorgyan, H. R.; Shahkhatuni, K. G.; Chukhadzhyan, El. O.; Ayrapetyan, L. V.; Khachatryan, A. A.
- Abstract
The review discusses intramolecular cyclization of ammonium salts containing a 4-hydroxybut-2- yn-1-yl group in combination with various π4-fragments, as well as mechanisms of cyclization and intramolecular recyclization of the resulting 4-(hydroxymethyl)dihydroisoindolium salts and their fused analogs. The process is accompanied by neither ring expansion nor contraction, and a pharmacophoric 1,3-dihydrofuran ring is formed instead of dihydroisoindolium fragment. The effects of electronic and structural factors on the intramolecular cyclization and recyclization processes are considered.
- Subjects
RING formation (Chemistry); AMMONIUM salts; HYDROXYMETHYL compounds; MOLECULAR interactions; DIHYDROFURANS
- Publication
Russian Journal of Organic Chemistry, 2018, Vol 54, Issue 4, p517
- ISSN
1070-4280
- Publication type
Article
- DOI
10.1134/S1070428018040012