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- Title
Hepatic miR-122 expression correlated with IL-28B genetic polymorphisms in hepatocellular carcinoma patients with living donor liver transplantation.
- Authors
Chih-Chi Wang; Kuang-Tzu Huang; Kuang-Den Chen; Li-Wen Hsu; Chih-Che Lin; King-Wah Chiu
- Abstract
Hepatocellular carcinoma (HCC) recurrence after living donor liver transplantation (LDLT) remains problematic. The genetic and molecular characteristics of patients may affect HCC recurrence. We evaluated the effects of microRNA-122 (miR-122) and interleukin-28B (IL-28B) genetic polymorphisms on patients with HCC following LDLT in 60 patients. MiR-122 and IL-28B polymorphisms were evaluated in plasma and liver tissues after LDLT. HBV, HCV, dual HBV/HCV infection, and non-B non-C were detected in 26, 22, 3, and 9 patients, respectively, over a median follow-up time of 20.5 (10-33) months. miR-122 was significantly higher in the liver than in the plasma of patients with HBV, HCV, dual HBV/HCV, and non-B non-C. Hepatic miR-122 expression was significantly higher for genotype TT and genotype TT plus GT (p = 0.005) compared with genotype GG of IL-28B rs8099917 and significantly higher in > 6% fatty liver than in < 5% or no fatty liver. In conclusion, high hepatic miR-122 was correlated with the IL-28B rs8099917 genotypes TT and GT and with > 6% fatty liver and, thus, may play a major role in HCC.
- Subjects
MICRORNA; LIVER transplantation; HEPATOCELLULAR carcinoma; GENETIC polymorphisms; FATTY liver; HEPATITIS B virus
- Publication
ScienceAsia, 2021, Vol 47, Issue 5, p578
- ISSN
1513-1874
- Publication type
Article
- DOI
10.2306/scienceasia1513-1874.2021.078