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- Title
Differences in time-domain and spectral indexes of skin-surface laser-Doppler signals between controls and breast-cancer subjects.
- Authors
Hsiu, Hsin; Chen, Chao-Tsung; Hung, Shuo-Hui; Chen, Guan-Zhang; Huang, Yu-Ling
- Abstract
BACKGROUND: There is an urgent need to improve the early diagnosis of breast cancer. OBJECTIVE: The present study applied spectral and beat-to-beat analyses to laser-Doppler (LDF) data sequences measured on the skin surface on the back of the right hands, with the aim of comparing the different peripheral microcirculatory-blood-flow (MBF) perfusion condition between breast-cancer and control subjects. METHODS: ECG and LDF signals were obtained simultaneously and noninvasively from 23 breast-cancer patients and 23 age-matched control subjects. Time-domain beat-to-beat indexes and their variability parameters were calculated. Spectral indexes were calculated using the Morlet wavelet transform. RESULTS: The beat-to-beat LDF pulse width and its variability were significantly smaller in cancer patients than in the controls. The energy contributions of endothelial-, neural-, and myogenic-related frequency bands were also significantly smaller in cancer patients. CONCLUSIONS: The present study has revealed significant differences in the beat-to-beat and spectral indexes of skin-surface-acquired LDF signals between control subjects and breast-cancer patients. This illustrates that LDF indexes may be useful for monitoring the changes in the MBF perfusion condition induced by breast cancer. Since the breast-cancer patients were at TNM stages 0– 2, the present findings may aid the development of indexes for detecting breast cancer.
- Subjects
TIME-domain analysis; LASER Doppler velocimeter; BREAST cancer diagnosis; MICROCIRCULATION disorders; CANCER patients
- Publication
Clinical Hemorheology & Microcirculation, 2018, Vol 69, Issue 3, p371
- ISSN
1386-0291
- Publication type
Article
- DOI
10.3233/CH-170295