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- Title
Regenerative medicine: Stroke survivor and carer views and motivations towards a proposed stem cell clinical trial using placebo neurosurgery.
- Authors
Cunningham, Nicola A.; Abhyankar, Purva; Cowie, Julie; Galinsky, Jayne; Methven, Karen
- Abstract
Background Few studies explore stroke survivor views and motivations towards stem cell therapy ( SCT). This qualitative study explores the views and motivations of both stroke survivors and their partners/carers towards a proposed 2-arm Phase III Randomised Controlled Trial ( RCT) comparing intracerebral insertion of stem cells with placebo neurosurgery in stroke survivors with disability. Objective To explore views and motivations towards a proposed 2-arm stem cell trial and identify factors that may impede and enhance participation. Design This study adopts a naturalistic design to explore the complexity of this field, employing a participatory action-research approach comprising a specialized Conversation (World) Café form of focus group. Data were collected via 5 Conversation Cafés with stroke survivors (age 40-75) and partners/carers between June and October 2016. Of 66 participants, 53 (31 male, 22 female) were stroke survivors and 13 (6 female, 7 male) were partners/carers. Qualitative data were analysed using a thematic approach. Discussion and Conclusion Stroke survivor views and motivations reflect anticipation of the personal and future benefits of regenerative medicine. Partners/carers sought to balance the value of stroke survivor hope with carrying the weight of hope as carer, a conflict burden adding to known caregiver burden. All participants expressed the need for during and post-trial psychological support. This study provides a rare opportunity to explore the prospective views and motivations of stroke survivors and their partners/carers towards a proposed Phase III 2-arm RCT. This adds weight to qualitative evidence exploring capacity, consent, decision making, perceptions of treatment risk and supports required for clinical trial participation.
- Subjects
STROKE treatment; ATTITUDE (Psychology); PSYCHOLOGY of caregivers; CLINICAL trials; FOCUS groups; MOTIVATION (Psychology); NEUROSURGERY; PATIENT participation; QUALITATIVE research; STEM cell research; JUDGMENT sampling; DATA analysis; THEMATIC analysis; PATIENTS' attitudes; STROKE patients; PSYCHOLOGY
- Publication
Health Expectations, 2018, Vol 21, Issue 1, p367
- ISSN
1369-6513
- Publication type
Article
- DOI
10.1111/hex.12632