We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Principles of Diagnosis and Management in the Ovarian Hyperstimulation Syndrome.
- Authors
ONOFRIESCU, ALINA; LUCA, A.; BORS, A.; HOLICOV, M.; ONOFRIESCU, M.; VULPOI, CARMEN
- Abstract
Ovarian hyperstimulation syndrome (OHSS) is the most serious consequence of ovulation induction and in vitro fertilisation (IVF), potentially resulting in death in its extreme manifestation. How best to manage this condition has been the subject of considerable study, with primary emphasis on risk recognition before commencing the IVF stimulation sequence. The exact etiology of OHSS remains unknown. The aim of this guideline is to provide clinicians with up-to-date information about the diagnosis and treatment of OHSS, based upon the best available evidence. This guideline covers outpatient management, criteria for hospital admission and basic inpatient management. Intensive care management of OHSS is not covered in detail. OHSS is an exaggerated response to ovulation induction with FSH and HCG. OHSS is a self-limiting disorder with a broad spectrum of clinical manifestations related to increased capillary permeability and fluid retention mediated by many inflammatory mediators including vascular endothelium growth factor. OHSS is a systemic disease resulting from vasoactive products released by hyperstimulated ovaries. The pathophysiology of OHSS is characterized by increased capillary permeability, leading to leakage of fluid from the vascular compartment, with third space fluid accumulation and intravascular dehydration. Severe manifestations include a tendency to develop thrombosis, renal and liver dysfunction and acute respiratory distress syndrome (ARDS), causing serious morbidity. The role of this guideline is to outline the risk factors, clinical features and appropriate management of severe OHSS. The guidelines also aim at assisting the determination of the appropriate site of care.
- Subjects
OVARIAN hyperstimulation syndrome; OVARIAN diseases; DIAGNOSIS; THERAPEUTICS
- Publication
Current Health Sciences Journal, 2013, Vol 39, Issue 3, p187
- ISSN
2067-0656
- Publication type
Article