We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Analysis of Gait Disturbance in Glut 1 Deficiency Syndrome.
- Authors
Blumenschine, Michelle; Montes, Jacqueline; Rao, Ashwini K.; Engelstad, Kristin; De Vivo, Darryl C.
- Abstract
Anticipating potential therapies for Glut 1 deficiency syndrome (Glut1DS) emphasizes the need for effective clinical outcome measures. The 6-minute walk test is a well-established outcome measure that evaluates walking ability in neurological diseases. Twenty-one children with Glut 1 deficiency syndrome and 21 controls performed the 6-minute walk test. Fatigue was determined by comparing distance walked in the first and sixth minutes. Gait was analyzed by stride length, velocity, cadence, base of support, and percentage time in double support. Independent sample t-tests examined differences between group. Repeated-measures analysis of variance evaluated gait parameters over time. Glut 1 deficiency syndrome patients walked less (P < .05), had slower velocities (P < .0001), had shorter stride lengths (P < .0001), spent more time in double support (P < .001), and had increasing variability in base of support (P = .009). Glut 1 deficiency syndrome patients have impaired motor performance, walk more slowly, and have poor balance. The 6-minute walk test with gait analysis may serve as a useful outcome measure in clinical trials in Glut 1 deficiency syndrome.
- Subjects
GLUCOSE transporter 1 deficiency syndrome; GAIT disorders; NEUROLOGICAL disorders; MOTOR ability; BALANCE disorders; PATIENTS; THERAPEUTICS
- Publication
Journal of Child Neurology, 2016, Vol 31, Issue 13, p1483
- ISSN
0883-0738
- Publication type
Article
- DOI
10.1177/0883073816661662