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- Title
A novel strategy for the treatment of melanoma.
- Abstract
This article, published in the British Journal of Dermatology, discusses a novel strategy for the treatment of melanoma, the most aggressive type of skin cancer. While immune checkpoint blockade (ICB) therapies have been successful in treating melanoma, approximately half of patients do not respond to these treatments. The article focuses on the interaction between sialic acid, a sugar molecule found on melanoma cells, and Siglecs, which are found on immune system cells. This interaction dampens the immune response against melanoma, and the article explores current approaches to block this interaction as a potential novel therapy for melanoma. The authors emphasize the importance of studying this interaction to improve melanoma treatment and the responsiveness to ICB therapies.
- Subjects
SKIN cancer; MELANOMA; IMMUNE checkpoint proteins; ACADEMIC medical centers
- Publication
British Journal of Dermatology, 2024, Vol 190, Issue 5, pe51
- ISSN
0007-0963
- Publication type
Article
- DOI
10.1093/bjd/ljae117