We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Perioperative Effects and Safety of Nesiritide Following Cardiac Surgery in Children.
- Authors
Simsic, Janet M.; Scheurer, Mark; Tobias, Joseph D.; Berkenbosch, John; Schechter, William; Madera, Freddie; Weinstein, Samuel; Michier, Robert E.
- Abstract
Nesiritide (Natrecor, Scios Inc), human B-type natriuretic peptide, has hemodynamic effects that may be beneficial in pediatric patients after cardiac surgery. Experience with nesiritide and pediatrics is limited. The purpose of this study was to evaluate perioperative effects and safety of nesiritide in pediatric cardiothoracic surgery. Seventeen patients with congenital heart disease undergoing cardiac surgery were given a loading dose (1 μg/kg) while on cardiopulmonary bypass (constant flow) followed by continuous infusion for 24 furors (0.01 μg/kg/min ⊗ 6 hours, then 0.02 μg/kg/min ⊗ 18 hours). A 7% decrease in mean blood pressure was seen following nesiritide loading dose on cardiopulmonary bypass. No patient required intervention for hypotension while receiving nesiritide load or infusion. Nesiritide load during surgery and continuous infusion after cardiac surgery in pediatric patients resulted in no significant hemodynamic compromise.
- Subjects
CARDIAC surgery; HEMODYNAMICS; JUVENILE diseases; HEART abnormalities; CONGENITAL heart disease; CHILDREN'S health; ATRIAL natriuretic peptides
- Publication
Journal of Intensive Care Medicine, 2006, Vol 21, Issue 1, p22
- ISSN
0885-0666
- Publication type
Article
- DOI
10.1177/0885066605282532