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- Title
Severe acute respiratory syndrome coronavirus 2 indirectly damages kidney structures.
- Authors
Dargelos, Mathilde; Couturier, Aymeric; Ferlicot, Sophie; Goujon, Jean-Michel; Roque-Afonso, Anne-Marie; Gault, Elyanne; Touchard, Guy; Ory, Cecile; Kaaki, Sihem; Vilaine, Eve; Essig, Marie; Massy, Ziad A
- Abstract
Background The objectives were to characterize Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) disease 2019 (COVID-19) in patients with acute kidney injury (AKI). Methods Kidney biopsy samples in two Caucasian patients and one African with COVID-19 AKI were investigated. Results All patients had a high-level non-selective glomerular proteinuria. SARS-CoV-2 samples by real-time polymerase chain reaction (RT- PCR) assay were all-negative, as well as for virus particles in the kidney by electron microscopy. The three patients and patients with other AKI did not differ significantly with regard to angiotensin-converting enzyme 2 and transmembrane protease serine 2 kidney staining. Conclusions The kidney damage particularly in Caucasians in COVID-19 seems to be an AKI, possibly by the systemic inflammatory response.
- Subjects
COVID-19; ANGIOTENSIN converting enzyme; RENAL biopsy; SARS-CoV-2; KIDNEYS
- Publication
Clinical Kidney Journal, 2020, Vol 13, Issue 6, p1101
- ISSN
2048-8505
- Publication type
Article
- DOI
10.1093/ckj/sfaa209