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- Title
Immunogenicity and Safety of a Third COVID-19 BNT162b2 mRNA Vaccine Dose in 5- to 11-Year Olds.
- Authors
Simões, Eric A F; Klein, Nicola P; Sabharwal, Charu; Gurtman, Alejandra; Kitchin, Nicholas; Ukkonen, Benita; Korbal, Piotr; Zou, Jing; Xie, Xuping; Sarwar, Uzma N; Xu, Xia; Lockhart, Stephen; Cunliffe, Luke; Lu, Claire; Ma, Hua; Swanson, Kena A; Koury, Kenneth; Shi, Pei-Yong; Cooper, David; Türeci, Ӧzlem
- Abstract
In this ongoing study, substantially increased ancestral SARS-CoV-2 neutralizing responses were observed 1 month after a third 10-µg BNT162b2 dose given to 5 to 11-year olds versus neutralizing responses post-dose 2. After dose 3, increased neutralizing responses against Omicron BA.1 and BA.4/BA.5 strains were also observed. The safety/tolerability profile was acceptable. (NCT04816643)
- Subjects
IMMUNOGLOBULINS; CONFIDENCE intervals; COVID-19 vaccines; VACCINE immunogenicity; BLOOD collection; LYMPHATIC diseases; MESSENGER RNA; RESEARCH funding; DESCRIPTIVE statistics; NEUTRALIZATION tests; LONGITUDINAL method; CHILDREN
- Publication
Journal of the Pediatric Infectious Diseases Society, 2023, Vol 12, Issue 4, p234
- ISSN
2048-7193
- Publication type
Article
- DOI
10.1093/jpids/piad015