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- Title
Prevention of clinical and histological signs of proteolipid protein (PLP)-induced experimental allergic encephalomyelitis (EAE) in mice by the water-soluble carbon monoxide-releasing molecule (CORM)-A1.
- Authors
Fagone, P.; Mangano, K.; Quattrocchi, C.; Motterlini, R.; Di Marco, R.; Magro, G.; Penacho, N.; Romao, C. C.; Nicoletti, F.
- Abstract
We have evaluated the effects of the carbon monoxide-releasing molecule CORM-A1 [Na(BHCO); ALF421] on the development of relapsing-remitting experimental allergic encephalomyelitis (EAE) in SJL mice, an established model of multiple sclerosis (MS). The data show that the prolonged prophylactic administration of CORM-A1 improves the clinical and histopathological signs of EAE, as shown by a reduced cumulative score, shorter duration and a lower cumulative incidence of the disease as well as milder inflammatory infiltrations of the spinal cords. This study suggests that the use of CORM-A1 might represent a novel therapeutic strategy for the treatment of multiple sclerosis.
- Subjects
ALLERGIC encephalomyelitis; CARBON monoxide; DISEASE relapse prevention; MULTIPLE sclerosis; HISTOPATHOLOGY; SPINAL cord diseases; LABORATORY mice; ALLERGY treatment; THERAPEUTICS
- Publication
Clinical & Experimental Immunology, 2011, Vol 163, Issue 3, p368
- ISSN
0009-9104
- Publication type
Article
- DOI
10.1111/j.1365-2249.2010.04303.x