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- Title
Granulocyte-colony-stimulating-factor-producing hepatocellular carcinoma.
- Authors
Yamamoto, Sumie; Takashima, Shuji; Ogawa, Hiroyuki; Kuroda, Toshifumi; Yamamoto, Mitsunari; Takeda, Akira; Nakmaura, Hideji; Yamamoto, S; Takashima, S; Ogawa, H; Kuroda, T; Yamamoto, M; Takeda, A; Nakmaura, H
- Abstract
Patients with hepatocellular carcinoma (HCC) rarely show marked granulocytosis. We report an interesting case of rapidly growing poorly differentiated HCC associated with marked granulocytosis. The blood leukocyte count decreased following several treatments for HCC, including transcatheter arterial embolization, and increased again along with tumor regrowth. The serum levels of granulocyte colony-stimulating factor (G-CSF) were markedly elevated, and immunohistochemical study showed G-CSF staining in the cytoplasm of certain HCC cells. These findings confirm that HCC in this case was a G-CSF-producing tumor.
- Subjects
LIVER cancer; GRANULOCYTES; COLONY-stimulating factors (Physiology)
- Publication
Journal of Gastroenterology, 1999, Vol 34, Issue 5, p640
- ISSN
0944-1174
- Publication type
journal article
- DOI
10.1007/s005350050387