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- Title
Guide for judicious use of the paracetamol absorption technique in a study of gastric emptying rate of liquids.
- Authors
Sanaka, Masaki; Kuyama, Yasushi; Yamanaka, Masami; Sanaka, M; Kuyama, Y; Yamanaka, M
- Abstract
The paracetamol absorption technique, a widely used method for evaluating the gastric emptying rate of liquids, appears to be performed inappropriately, resulting from a lack of consideration of pharmacokinetics in paracetamol absorption. This review suggests that appropriate study designs and logical choice of the parameters for the rate of paracetamol absorption are the cornerstone of reliable investigation of gastric emptying using the paracetamol method.
- Subjects
ACETAMINOPHEN; ABSORPTION (Physiology); GASTRIC secretions; PHARMACOKINETICS; GASTROINTESTINAL motility; INTESTINAL absorption; MATHEMATICAL models; MEDICAL protocols; ORAL drug administration; RESEARCH evaluation; WATER; THEORY; CROSS-sectional method
- Publication
Journal of Gastroenterology, 1998, Vol 33, Issue 6, p785
- ISSN
0944-1174
- Publication type
journal article
- DOI
10.1007/s005350050177