We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Predictive value of hepcidin in patients with chronic hepatitis C infection among Egyptians.
- Authors
Ismail, Hisham A.; Ebrahim, Doaa; El-Assal, Mohamed A.; Abozeid, Mai; Abdelsameea, Eman
- Abstract
Background: Iron is essential for oxygen transport and energy production, but it is potentially toxic through generation of oxidative stress. Patients with chronic hepatitis C (CHC) infection frequently have serum and hepatic iron overload, which is a cofactor for disease progression. Human hepcidin, a 25-amino acid peptide produced by hepatocytes, is considered a new mediator of innate immunity and master iron-regulatory hormone. Aim: To determine clinical relevance of hepcidin in patients with CHC infection and whether it correlates with markers of hepatic inflammation and iron status in those patients. Patients and methods: This study included 80 (54 patients and 26 controls) individual who were matched in age and sex. Serum hepcidin levels and serum iron status were determined. Their levels were correlated with each other and with other laboratory parameters. Results: Mean serum hepcidin levels were significantly lower in patients with CHC than in controls (P =0.001). Patients with CHC had significantly higher mean values of serum iron and ferritin than controls (P =0.001 and 0.017, respectively). There was a significant negative correlation between hepcidin levels and alanine aminotransferase, (r =−0.454, P <0.001), aspartate aminotransferase (r =−0.440; P =0.001), and serum iron (r =−0.453, P =0.001), whereas hepcidin levels correlated positively with ferritin (r =0.105, P =0.017), platelets count (r =0.245, P =0.028), and hepatitis C virus RNA level (r =0.308, P =0.023). Conclusion: Adequate levels of hepcidin may improve severity of liver disease and may contribute to management of patients with CHC.
- Publication
Egyptian Liver Journal, 2018, Vol 8, Issue 1, p12
- ISSN
2090-6218
- Publication type
Article
- DOI
10.1097/01.ELX.0000530863.06773.be