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- Title
Meta-GWAS for quantitative trait loci identification in soybean.
- Authors
Shook, Johnathon M.; Jiaoping Zhang; Jones, Sarah E.; Singh, Arti; Diers, Brian W.; Singh, Asheesh K.
- Abstract
We report a meta-Genome Wide Association Study involving 73 published studies in soybean [Glycine max L. (Merr.)] covering 17,556 unique accessions, with improved statistical power for robust detection of loci associated with a broad range of traits. De novo GWAS and meta-analysis were conducted for composition traits including fatty acid and amino acid composition traits, disease resistance traits, and agronomic traits including seed yield, plant height, stem lodging, seed weight, seed mottling, seed quality, flowering timing, and pod shattering. To examine differences in detectability and test statistical power between single- and multi-environment GWAS, comparison of meta-GWAS results to those from the constituent experiments were performed. Using meta-GWAS analysis and the analysis of individual studies, we report 483 peaks at 393 unique loci. Using stringent criteria to detect significant marker-trait associations, 59 candidate genes were identified, including 17 agronomic traits loci, 19 for seed-related traits, and 33 for disease reaction traits. This study identified potentially valuable candidate genes that affect multiple traits. The success in narrowing down the genomic region for some loci through overlapping mapping results of multiple studies is a promising avenue for community-based studies and plant breeding applications.
- Subjects
PLANT breeding; STATISTICAL power analysis; DISEASE resistance of plants; AMINO acids; COMPOSITION of seeds; SEED yield; OILSEEDS
- Publication
G3: Genes | Genomes | Genetics, 2021, Vol 11, Issue 7, p1
- ISSN
2160-1836
- Publication type
Article
- DOI
10.1093/g3journal/jkab117