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- Title
Bone CLARITY: Clearing, imaging, and computational analysis of osteoprogenitors within intact bone marrow.
- Authors
Greenbaum, Alon; Chan, Ken Y.; Dobreva, Tatyana; Brown, David; Balani, Deepak H.; Boyce, Rogely; Kronenberg, Henry M.; McBride, Helen J.; Gradinaru, Viviana
- Abstract
The article presents the study of the Bone CLARITY bone tissue clearing method. It highlights its potential in detecting fluorescence of Sox9-tdTomato+ osteoprogenitor cells in the vertebral column, tibia and femur of transgenic mice. It also outlines the clearing-imaging pipeline and its value through quantification of changes in the cells' population.
- Subjects
BONE cells; FLUORESCENCE; PROGENITOR cells; TRANSGENIC mice; FEMUR physiology
- Publication
Science Translational Medicine, 2017, Vol 9, Issue 387, p1
- ISSN
1946-6234
- Publication type
Article
- DOI
10.1126/scitranslmed.aah6518