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- Title
Chimpanzee adenovirus– and MVA-vectored respiratory syncytial virus vaccine is safe and immunogenic in adults.
- Authors
Green, Christopher A.; Scarselli, Elisa; Sande, Charles J.; Thompson, Amber J.; de Lara, Catherine M.; Taylor, Kathryn S.; Haworth, Kathryn; Sorbo, Mariarosaria Del; Angus, Brian; Siani, Loredana; Di Marco, Stefania; Traboni, Cinzia; Folgori, Antonella; Colloca, Stefano; Capone, Stefania; Vitelli, Alessandra; Cortese, Riccardo; Klenerman, Paul; Nicosia, Alfredo; Pollard, Andrew J.
- Abstract
The article offers information on the efficacy of chimpanzee adenovirus, PanAd3-RSV, and modified vaccinia virus Ankara, MVA-RSV in the vaccination of respiratory syncytial virus (RSV) infection. It mentions the limitation of palivizumab monoclonal antibody prophylaxis; talks about the absence of immunopathology associated with enhanced respiratory disease (ERD) after vaccination; and investigated the cellular immunogenicity of the vaccines.
- Subjects
RESPIRATORY syncytial virus infection vaccines; PALIVIZUMAB; MONOCLONAL antibodies; PREVENTIVE medicine; IMMUNOPATHOLOGY; RESPIRATORY diseases; THERAPEUTICS
- Publication
Science Translational Medicine, 2015, Vol 7, Issue 300, p1
- ISSN
1946-6234
- Publication type
Article
- DOI
10.1126/scitranslmed.aac5745