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- Title
Advances in IL-7 Research on Tumour Therapy.
- Authors
Fu, Chunxue; Zhang, Xinqiang; Zhang, Xinyu; Wang, Dan; Han, Shuxin; Ma, Zhenghai
- Abstract
Interleukin-7 (IL-7) is a versatile cytokine that plays a crucial role in regulating the immune system's homeostasis. It is involved in the development, proliferation, and differentiation of B and T cells, as well as being essential for the differentiation and survival of naïve T cells and the production and maintenance of memory T cells. Given its potent biological functions, IL-7 is considered to have the potential to be widely used in the field of anti-tumour immunotherapy. Notably, IL-7 can improve the tumour microenvironment by promoting the development of Th17 cells, which can in turn promote the recruitment of effector T cells and NK cells. In addition, IL-7 can also down-regulate the expression of tumour growth factor-β and inhibit immunosuppression to promote anti-tumour efficacy, suggesting potential clinical applications for anti-tumour immunotherapy. This review aims to discuss the origin of IL-7 and its receptor IL-7R, its anti-tumour mechanism, and the recent advances in the application of IL-7 in tumour therapy.
- Subjects
B cells; HOMEOSTASIS; B cell differentiation; IMMUNOLOGIC memory; KILLER cells; T cell differentiation; T helper cells; B cell receptors
- Publication
Pharmaceuticals (14248247), 2024, Vol 17, Issue 4, p415
- ISSN
1424-8247
- Publication type
Article
- DOI
10.3390/ph17040415