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- Title
Effects of In-Hospital Exercise on Frailty in Patients with Hepatocellular Carcinoma.
- Authors
Tsuchihashi, Jin; Koya, Shunji; Hirota, Keisuke; Koga, Noboru; Narao, Hayato; Tomita, Manabu; Kawaguchi, Takumi; Hashida, Ryuki; Nakano, Dan; Tsutsumi, Tsubasa; Yoshio, Sachiyo; Matsuse, Hiroo; Sanada, Taku; Notsumata, Kazuo; Torimura, Takuji
- Abstract
Simple Summary: Frailty including physical inactivity is associated with the survival of patients with hepatocellular carcinoma (HCC). We aimed to investigate the effects of in-hospital exercise on frailty in patients with HCC. This was a multi-center observational study. Patients with HCC were classified into exercise (n = 114) and non-exercise (n = 67) groups. The exercise group was treated with a mixture of aerobic and resistance exercises (20–40 min/day, median four days). Frailty was assessed using the liver frailty index (LFI). In multivariate analysis, exercise (odds ratio (OR) 2.38, 95% confidence interval (CI) 1.240–4.570, p = 0.0091) as an independent factor for the improvement of LFI. In the decision-tree analysis, exercise was identified as an initial classifier associated with the improvement of LFI. We demonstrated that in-hospital exercise improved frailty in patients with HCC, which was confirmed by propensity score matching analysis. Thus, in-hospital exercise may be beneficial for improving physical function in patients with HCC. Frailty including physical inactivity is associated with the survival of patients with hepatocellular carcinoma (HCC). We aimed to investigate the effects of in-hospital exercise on frailty in patients with HCC. This was a multi-center observational study. Patients with HCC were classified into exercise (n = 114) and non-exercise (n = 67) groups. The exercise group was treated with a mixture of aerobic and resistance exercises (20–40 min/day, median four days). Frailty was assessed using the liver frailty index (LFI). Factors for changes in LFI were examined by multivariate and decision-tree analyses. The factors were also examined after propensity score matching. During hospitalization, LFI was significantly improved in the exercise group compared to the non-exercise group (ΔLFI −0.17 vs. −0.02, p = 0.0119). In multivariate analysis, exercise (odds ratio (OR) 2.38, 95% confidence interval (CI) 1.240–4.570, p = 0.0091) and females (OR 2.09; 95%CI, 1.062–4.109; p = 0.0328) were identified as independent factors for the improvement of LFI. In the decision-tree analysis, exercise was identified as an initial classifier associated with the improvement of LFI. Similar findings were also seen in the propensity score matching analyses. We demonstrated that in-hospital exercise improved frailty in patients with HCC. Thus, in-hospital exercise may be beneficial for improving physical function in patients with HCC.
- Subjects
AEROBIC exercises; CANCER patients; CONFIDENCE intervals; DECISION trees; EXERCISE physiology; FRAIL elderly; HEPATOCELLULAR carcinoma; HOSPITAL care; MEDICAL cooperation; MULTIVARIATE analysis; SCIENTIFIC observation; RESEARCH; DESCRIPTIVE statistics; RESISTANCE training; ODDS ratio
- Publication
Cancers, 2021, Vol 13, Issue 2, p194
- ISSN
2072-6694
- Publication type
Article
- DOI
10.3390/cancers13020194