We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Inhibition of DNA Repair Mechanisms and Induction of Apoptosis in Triple Negative Breast Cancer Cells Expressing the Human Herpesvirus 6 U94.
- Authors
Caccuri, Francesca; Sommariva, Michele; Marsico, Stefania; Giordano, Francesca; Zani, Alberto; Giacomini, Arianna; Fraefel, Cornel; Balsari, Andrea; Caruso, Arnaldo
- Abstract
Triple-negative breast cancer (TNBC) accounts for 15–20% of all breast cancers. In spite of initial good response to chemotherapy, the prognosis of TNBC remains poor and no effective specific targeted therapy is readily available. Recently, we demonstrated the ability of U94, the latency gene of human herpes virus 6 (HHV-6), to interfere with proliferation and with crucial steps of the metastatic cascade by using MDA-MB 231 TNBC breast cancer cell line. U94 expression was also associated with a partial mesenchymal-to-epithelial transition (MET) of cells, which displayed a less aggressive phenotype. In this study, we show the ability of U94 to exert its anticancer activity on three different TNBC cell lines by inhibiting DNA damage repair genes, cell cycle and eventually leading to cell death following activation of the intrinsic apoptotic pathway. Interestingly, we found that U94 acted synergistically with DNA-damaging drugs. Overall, we provide evidence that U94 is able to combat tumor cells with different mechanisms, thus attesting for the great potential of this molecule as a multi-target drug in cancer therapy.
- Subjects
CELL proliferation; ANTINEOPLASTIC agents; APOPTOSIS; BREAST tumors; CELL cycle; CELL lines; DNA; HERPESVIRUSES; METASTASIS; MICROBIAL genetics; PHARMACODYNAMICS
- Publication
Cancers, 2019, Vol 11, Issue 7, p1006
- ISSN
2072-6694
- Publication type
Article
- DOI
10.3390/cancers11071006