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- Title
Obesity as a Conditioning Factor for High-Altitude Diseases.
- Authors
San Martin, Rocío; Brito, Julio; Siques, Patricia; León-Velarde, Fabiola
- Abstract
Obesity, a worldwide epidemic, has become a major health burden because it is usually accompanied by an increased risk for insulin resistance, diabetes, hypertension, cardiovascular diseases, and even some kinds of cancer. It also results in associated increases in healthcare expenditures and labor and economic consequences. There are also other fields of medicine and biology where obesity or being overweight play a major role, such as high-altitude illnesses (acute mountain sickness, hypoxic pulmonary hypertension, and chronic mountain sickness), where an increasing relationship among these two morbid statuses has been demonstrated. This association could be rooted in the interactions between obesity-related metabolic alterations and critical ventilation impairments due to obesity, which would aggravate hypobaric hypoxia at high altitudes, leading to hypoxemia, which is a trigger for developing high-altitude diseases. This review examines the current literature to support the idea that obesity or overweight could be major conditioning factors at high altitude.
- Subjects
OBESITY; METABOLIC disorders; INSULIN resistance; HYPERTENSION; MEDICAL care costs; MOUNTAIN sickness
- Publication
Obesity Facts: The European Journal of Obesity, 2017, Vol 10, Issue 4, p363
- ISSN
1662-4025
- Publication type
Article
- DOI
10.1159/000477461