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- Title
Ceftobripole: Experience in staphylococcal bacteremia.
- Authors
Soriano, Alex; Morata, Laura
- Abstract
Ceftobiprole is a new cephalosporin with an extended spectrum activity against the majority of microorganisms isolated in bacteremia including methicillin-susceptible (MSSA) and -resistant S. aureus (MRSA). This antibiotic has demonstrated a potent activity against MRSA in animal models of endocarditis in monotherapy but particularly in combination with daptomycin, suggesting that this combination could be a future option to improve the outcome of staphylococcal endovascular infections. In addition, the extended-spectrum ceftobiprole activity, including coagulase-negative staphylococci, Enterococcus faecalis, Enterobacteriaceae and Pseudomonas aeruginosa represents an advantage for use as empirical therapy in bacteremia potentially caused by a broad spectrum of microorganisms, such as in catheter-related bacteremia.
- Subjects
CEPHALOSPORINS; BACTEREMIA treatment; METHICILLIN-resistant staphylococcus aureus treatment; ENDOCARDITIS; COMBINATION drug therapy
- Publication
Revista Española de Quimioterapia, 2019, Vol 32, p24
- ISSN
0214-3429
- Publication type
Article