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- Title
Thyroid Carcinoma Patients Correlated with Cytomegalovirus by using Insitu Hybridization.
- Authors
Saeed, Noor Al-Huda Ali A. H.; Elhaboby, Ban Talib; Wahab Alsiadi, Wasan A.
- Abstract
Worldwide, the most common cancer-related deaths and poses one of the top ten most risk cancers globally in many countries, is the thyroid carcinoma. In human cancers, there are important factor associated with it . The viral agent is one of them which is involved in the spread of tumors, including thyroid cancers. So, the present study was designed to determine the relationship between Cytomegalovirus infection with some Iraqi patients who suffer from the thyroid carcinoma in tissue cancer from different site (papillary, follicular and lymph node) by using In Situ Hybridization Technique, related to their age, gender, site distribution, histological grade and the tumor stage. The sixty biopsies were randomly collected during the period between June 2017 until October 2018,CMV was detected in(28.3%)(17 out of 60 patients, the mean age was 39 years old, ranged between ( 27-72) years old, female to male ratio was (1.3 : 1) with 34 women and 26 men. The most of these cases were papillary carcinoma 39, followed by follicular 13 and the rest 8 cases were at the lymph node. Histological grades that involved were 37 well differentiated, 18 were poorly differentiated, and 5 were moderately differentiated. Tumor staging included 43 patients who fall in stage I and II, while the rest 17 patients fall in stage III and IV. Regarding to the positive results, CMV correlates in a highly significant association with each of (age, gender, grading, tumor stage, and site distribution at p<0.01). It could be concluded from that the in situ hybridization is useful in the clinical evaluation of patients with thyroid carcinoma. And suggested that the viral agent cytomegalovirus is involved in thyroid carcinogenesis and may play an important role in the malignant transformation of thyroid cancer.
- Subjects
THYROID cancer; BRAF genes; CYTOMEGALOVIRUSES; CYTOMEGALOVIRUS diseases; TUMOR classification; IN situ hybridization
- Publication
Indian Journal of Forensic Medicine & Toxicology, 2021, Vol 15, Issue 1, p2726
- ISSN
0973-9122
- Publication type
Article
- DOI
10.37506/ijfmt.v15i1.13811