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- Title
Two Hormones: Ghrelin and Leptin, Based on AMPK Signaling Pathway, Play a Role in Body Mass Control of Eothenomys miletus during Fasting in Kunming and Dali Regions.
- Authors
Ting Jia; Yu-Ting Liu; Hao Zhang; Wan-Long Zhu
- Abstract
Background: The ability to respond to global change and coexist with other species depends on phenotypic plasticity and physiological adaptation techniques of the same species living in various places differ according to the region. Methods: Eothenomys miletus from Kunming (KM) and Dali (DL) under fasting and refeeding acclimation, we examined the thermogenic properties and the associated physiological indicators in the AMP dependent protein kinase (AMPK) pathway. Result: The results demonstrated that energy consumption in E. miletus was decreased by fasting and that the process of survival adaption was signif icantly influenced by body mass, ghrelin concentration and AMPK activity. Following refeeding, pertinent physiological markers leveled off in the control group, demonstrating the high phenotypic plasticity of E. miletus and the critical role that leptin, ghrelin and AMPK pathways play in energy metabolism and environmental adaption during food fasting. Moreover, there may be a connection between geographical variations in physiological indicators under fasting conditions and variations in the ambient temperature and the food available to E. miletus in various places.
- Subjects
KUNMING (China); AMP-activated protein kinases; LEPTIN; PHYSIOLOGY; CELLULAR signal transduction; GHRELIN receptors; PROTEIN kinases; GHRELIN
- Publication
Indian Journal of Animal Research, 2024, Vol 58, Issue 3, p381
- ISSN
0367-6722
- Publication type
Article
- DOI
10.18805/IJAR.BF-1669