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- Title
Prevalence and factors associated with idiopathic hypercalciuria in HIV patients on combination antiretroviral therapy.
- Authors
Pocaterra D; Carenzi L; Ricci E; Minisci D; Schiavini M; Gervasoni C; Meraviglia P; Bevilacqua M; Rizzardini G; Bonfanti P
- Abstract
Idiopathic hypercalciuria may lead to bone loss via three pathogenic mechanisms described in HIV-negative patients: intestinal hyperabsorption, kidney loss and bone hyperabsorption. We conducted a cross-sectional study in a cohort of 217 HIV-positive antiretroviral-experienced patients, identifying hypercalciuria in 67 patients: the prevalence was 30.9% (95% confidence interval 27.4-37.0). The occurrence of hypercalciuria in subjects with normal values of parathormone may indicate an absorptive form of hypercalciuria. In this sample, other bone turnover markers and T-scores were not related to the condition. The results of this study show a high prevalence of idiopathic hypercalciuria in a group of antiretroviral-experienced patients. The consequences and the exact causes of this metabolic complication are not yet known and further investigation is needed.
- Publication
International Journal of STD & AIDS, 2010, Vol 21, Issue 12, p829
- ISSN
0956-4624
- Publication type
Journal Article