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- Title
Cerebrospinal Fluid and Serum Markers of Inflammation in Patients with Multiple Sclerosis.
- Authors
Eslami, Asma; Farrokhi, Mehrdad
- Abstract
Objective: Multiple sclerosis (MS) is the most common inflammatory demyelinating disease of the central nervous system (CNS). The canonical Th1 cytokine, interferon-gamma (IFN-γ), has diverse roles in innate and adaptive immunity, inflammation, Th1 responses, and suppression of autoimmunity and associated pathology in a context and disease specific manner. C-reactive protein (CRP) is an acute phase protein that contributes to innate and adaptive immunity and is induced by cytokines such as interleukin-6 (IL-6), IL-1, and tumor-necrosis factor-a (TNF-a). Material and Methods: Cerebrospinal fluid (CSF) and serum samples were recruited from relapsing remitting multiple sclerosis patients (n=40) and healthy subjects (n=40). CSF and serum level measurement of IFN- γ and CRP were performed using enzyme-linked immunosorbent assay (ELISA). Results: CSF and serum levels of IFN- γ and CRP were significantly higher in MS patients compared to healthy control group (P<0.01). We found positive correlations between the CSF and serum levels of IFN- γand expanded disability status scale (EDSS) of the MS patients (r=+0.80, P<0.01; r=+0.34 and P=0.03, respectively). Moreover, there was a significant association between the serum levels of CRP and EDSS of the patients (r=+0.54 and P<0.01). Conclusion: Our findings reveal the increased CSF and serum levels of IFN- γ and CRP in RRMS patients. Our data suggest that determining serum levels of IFN- γ and CRP could be useful for understanding and monitoring the inflammatory response in MS. Furthermore, CSF levels of IFN- γ is more reliable and useful than its serum levels for monitoring of severity of disability in MS patients.
- Subjects
MULTIPLE sclerosis; INFLAMMATION; SERUM
- Publication
Iranian Journal of Allergy, Asthma & Immunology, 2018, Vol 17, p294
- ISSN
1735-1502
- Publication type
Abstract