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- Title
Palladium‐Catalyzed C8‐Fluoroalkylation and C8‐Fluoroalkenylation of Naphthalenes by C−H Activation.
- Authors
Amistadi‐Revol, Hugo; Tremblais, Julie; Casaretto, Nicolas; Prévost, Sébastien
- Abstract
In this study, two novel C8‐functionalization methods of 1‐carbonylnaphthalenes were developed. Leveraging iodonium triflates as coupling partners, we disclose palladium‐catalyzed C8‐fluoroalkylation and C8‐fluoroalkenylation processes. These protocols exhibit broad applicability across diverse naphthalene derivatives, owing to carbonyl directing groups at the C1 position which can be retained for subsequent applications or selectively removed, enhancing the versatility of the developed methodologies.
- Subjects
CARBONYL group; IODONIUM salts; NAPHTHALENE derivatives
- Publication
European Journal of Organic Chemistry, 2024, Vol 27, Issue 20, p1
- ISSN
1434-193X
- Publication type
Article
- DOI
10.1002/ejoc.202400194