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- Title
Selective Synthesis of Functionalized 3(2H)‐Furanones via Tandem Michael Addition/Rearrangement/Cyclization Reaction of Aliphatic Alkynones: A Combined Experimental and Theoretical Study.
- Authors
Karnakova, Sofia O.; Kuzmin, Anton V.; Ushakov, Igor' A.; Shabalin, Dmitrii A.
- Abstract
A novel catalyst‐ and solvent‐controlled dimerization of aliphatic alkynones through tandem Michael addition/rearrangement/cyclization sequence has been developed. The elaborated protocol provides a convenient chemo‐, regio‐ and stereoselective access to rare 3(2H)‐furanones decorated with 2‐exo‐methylene and 4‐ethenyl functionalities. A comprehensive density functional theory (DFT) study of possible reaction mechanism including ab initio molecular dynamics (AIMD) simulations and quantum theory of atoms in molecules (QTAIM) analysis of various substrate/catalyst/solvent complexes has revealed the Janus‐like behavior of the employed sodium tert‐butoxide/toluene system that is responsible both for the chemoselectivity of the initial addition step and the inhibition of the final cyclization step.
- Subjects
RING formation (Chemistry); CHEMOSELECTIVITY; ATOMS in molecules theory; TOLUENE; DENSITY functional theory; MOLECULAR dynamics
- Publication
European Journal of Organic Chemistry, 2024, Vol 27, Issue 17, p1
- ISSN
1434-193X
- Publication type
Article
- DOI
10.1002/ejoc.202400133