We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
KI‐Mediated Chlorine Gas‐Free Synthesis of 3,3‐Dichloro‐2‐oxindole Derivatives.
- Authors
Li, Xuejian; Wang, Bangzhong; Li, Dong; Zhao, Jinfeng; Qu, Jingping; Zhou, Yuhan
- Abstract
An efficient and environmentally friendly methodology for 3,3‐dichlorination and 2‐oxidation of indole derivatives is described. Using KI as promotor, MCl (M=K, Na) as chlorine source, and oxone as oxidant, the reaction proceeds smoothly affording various functionalized 3,3‐dichloro‐2‐oxindoles in moderate to excellent yields. This strategy can also be extended to 3‐substituted indoles. With a broad substrate scope, it is a practical approach to 3,3‐disubstituted‐2‐oxindoles.
- Subjects
OXINDOLES; CHLORINE; INDOLE derivatives; PEROXYMONOSULFATE; INDOLE compounds; OXIDIZING agents
- Publication
European Journal of Organic Chemistry, 2023, Vol 26, Issue 15, p1
- ISSN
1434-193X
- Publication type
Article
- DOI
10.1002/ejoc.202201452