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- Title
Applications of Microarray Technology to Acute Myelogenous Leukemia.
- Authors
Goswami, Rashmi S.; Sukhai, Mahadeo A.; Thomas, Mariam; Reis, Patricia P.; Kamel-Reid, Suzanne
- Abstract
Microarray technology is a powerful tool, which has been applied to further the understanding of gene expression changes in disease. Array technology has been applied to the diagnosis and prognosis of Acute Myelogenous Leukemia (AML). Arrays have also been used extensively in elucidating the mechanism of and predicting therapeutic response in AML, as well as to further define the mechanism of AML pathogenesis. In this review, we discuss the major paradigms of gene expression array analysis, and provide insights into the use of software tools to annotate the array dataset and elucidate deregulated pathways and gene interaction networks. We present the application of gene expression array technology to questions in acute myelogenous leukemia; specifically, disease diagnosis, treatment and prognosis, and disease pathogenesis. Finally, we discuss several new and emerging array technologies, and how they can be further utilized to improve our understanding of AML.
- Subjects
DNA microarrays; ACUTE myeloid leukemia treatment; MEDICAL technology; BIOINFORMATICS; GENE expression; PROGNOSIS
- Publication
Cancer Informatics, 2009, Issue 7, p13
- ISSN
1176-9351
- Publication type
Article
- DOI
10.4137/CIN.S1015