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- Title
El factor de crecimiento de tejido conectivo (CTGF): factor clave en el inicio y la progresión del daño renal.
- Authors
Sánchez-López, E.; Rodrigues Díez, R.; Rodríguez Vita, J.; Rayego Mateos, S.; Rodriguez Díez, R. R.; Rodriguez García, E; Lavoz Barria, C.; Mezzano, S.; Egido, J.; Ortiz, A.; Ruiz-Ortega, M.; Selgas, R.
- Abstract
Connective tissue growth factor (CTGF) is increased in several pathologies associated with fibrosis, including multiple renal diseases. CTGF is involved in biological processes such as cell cycle regulation, migration, adhesion and angiogenesis. Its expression is regulated by various factors involved in renal damage, such as Angiotensin II, transforming growth factor-beta, high concentrations of glucose and cellular stress. CTGF is involved in the initiation and progression of renal damage to be able to induce an inflammatory response and promote fibrosis, identified as a potential therapeutic target in the treatment of kidney diseases. In this paper we review the main actions of CTGF in renal disease, the intracellular action mechanisms and therapeutic strategies for its blocking.
- Subjects
CONNECTIVE tissue development; FIBROSIS; CELL cycle regulation; CELL migration; CELL adhesion; NEOVASCULARIZATION; KIDNEY disease treatments
- Publication
Nefrologia, 2009, Vol 29, Issue 5, p382
- ISSN
0211-6995
- Publication type
Article