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- Title
A comparison of the amyloid β fibril-destabilizing activities of leaves among varieties of the mulberry.
- Authors
Khaengkhan, Parinda; Takahashi, Keita; Niidome, Tetsuhiro; Ichida, Masatoshi; Sugimoto, Hachiro; Harada, Shigeharu; Kamei, Kaeko
- Abstract
Accumulating evidence suggests that amyloid β-peptide (1-42) plays an important role in the etiology of Alzheimer's disease. In a previous study, we reported that mulberry leaf extract inhibits the amyloid β-peptide (1-42) fibril formation and protects hippocampal neurons against amyloid β-peptide (1-42)-induced cell death. In the present study, we compared the amyloid β (1-42) fibril-destabilizing activities of leaf extracts from 258 varieties of the mulberry. Our results showed that for proper utilization, it is necessary to screen mulberry leaves for high Aβ42 fibril-destabilizing activity.
- Subjects
AMYLOID; ALZHEIMER'S disease; MULBERRY; HIPPOCAMPUS (Brain); NEURONS; CELL death
- Publication
Journal of Insect Biotechnology & Sericology, 2009, Vol 78, Issue 3, p173
- ISSN
1346-8073
- Publication type
Article