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- Title
Vasoconstriction of the afferent arteriole and defective renal synthesis of nitric oxide in essential hypertension.
- Authors
Gomez-Alamillo, Carlos; Sanchez-Casajús, Angel; Sierra, Milagros; Huarte, Emma; Díez, Javier
- Abstract
This study was designed to investigate whether some relation exists between afferent arteriolar resistance (AAR) and the renal production of nitric oxide (NO) and prostacyclin (PGI2) in 21 patients with untreated essential hypertension and 20 normotensive controls. All subjects were studied in conditions of an unlimited Na+ diet both basally and after a four-hour amino acid infusion. AAR was calculated using Gomez's equations. Renal production of NO and PGI2 were assessed by radioimmunoassay of the urinary excretion of cGMP and 6-keto-PGF1α, respectively. Baseline AAR was higher (P < 0.01) in hypertensives than in normotensives. The baseline urinary excretion of 6-keto-PGF1α and cGMP were similar in the two groups of subjects. AAR diminished (P < 0.005) in normotensives and remained unchanged in hypertensives after amino acid infusion. Urinary excretion of 6-keto-PGF1α was increased similarly in the two groups of subjects after infusion. Urinary excretion of cGMP remained unchanged in normotensives and decreased by 31% in hypertensives after infusion. These findings suggest that afferent vasoconstriction present in hypertensive patients is unresponsive to the vasodilatory manoeuvre of amino acid infusion. This lack of response may be due to a defective renal synthesis of NO in these patients.
- Subjects
HYPERTENSION; VASOCONSTRICTION; RENAL circulation; NITRIC oxide; PROSTACYCLIN
- Publication
Kidney International, 1996, Vol 49, pS129
- ISSN
0085-2538
- Publication type
Article