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- Title
Low incidence of IgA nephropathy in Blacks.
- Authors
Jennette, J. Charles; Wall, Sherri D.; Wilkman, Alice S.
- Abstract
The clinical and pathologic features were evaluated in 106 lgA nephropathy patients identified in 1.753 consecutive patients undergoing renal biopsy in the southeastern United States. Special attention was paid to the proportion of Blacks among the lgA nephropathy patients compared with non-IgA nephropathy patients, and any differences in clinical or pathologic findings between Whites and Blacks with lgA nephropathy. The incidence lgA nephropathy was approximately six times lower in Blacks (6 out of 461) than in Whites (100 out of 1,292) undergoing renal biopsy (P < 0.001). There were no morphologic or immunohistopathologic differences between Whites and Blacks with IgA nephropathy. The only clinical difference was a marked shift in the male to female sex ratio from 3.5:1 in Whites to 1:5 in Blacks (P < 0.004). The low incidence and reversed sex ratio of IgA nephropathy in Blacks were also supported by a review of previously published data.
- Subjects
UNITED States; KIDNEY diseases; IGA glomerulonephritis; IMMUNOGLOBULIN A; NEPHROLOGY; RENAL biopsy; HEALTH of African Americans
- Publication
Kidney International, 1985, Vol 28, Issue 6, p944
- ISSN
0085-2538
- Publication type
Article
- DOI
10.1038/ki.1985.222