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- Title
Effect of intrathecal morphine on pain score in total hip arthroplasty.
- Authors
Mandarić, Anja; Orešković, Zrinka; Marić, Ivan; Žura, Marijana; Morović, Sandra
- Abstract
Introduction: The advantage of intrathecal morphine is due to its delivery into the subarachnoid space with direct access to opiate receptors and ion channels, while clinical duration of action can be as long as 20 hours. Joint replacement surgery is reported to be one of the most painful surgical procedures. The key factor for short postoperative length of stay and rapid functional recovery is pre-operative, intraoperative and postoperative analgesia. Spinal anaesthesia incorporating intrathecal morphine has been used as a systemic opioid-sparing technique. The most frequently investigated dose of intrathecal morphine was 100µg. Materials and Methods: In this study, spinal anaesthesia with the addition of morphine for intrathecal administration at a dose of 200 µg and 250 µg was administered to patients who underwent surgery for total hip arthroplasty and VAS pain scale was monitored postoperatively in the next 24 hours. The study group was compared to a group of patients who received standard intravenous analgesia postoperatively. Results: Intrathecal application of morphine improves pain management in the first 24 postoperative hours in comparison to a control group who has received a systemic combination of opioid and nonopioid analgesics as part of postoperative analgesia. Conclusions: The use of intrathecal morphine at a dose of 200 µg or 250 µg is an extremely good analgesic method in the postoperative period after surgery for total hip arthroplasty.
- Subjects
TOTAL hip replacement; ANALGESIA; SPINAL infusions; ARTHROPLASTY; ENDORPHIN receptors; MORPHINE; SUBARACHNOID space
- Publication
Rad Hrvatske Akademije Znanosti i Umjetnosti. Medicinske Znanosti, 2023, Vol 553, Issue 62/63, p54
- ISSN
1330-5301
- Publication type
Article
- DOI
10.21857/m8vqrtgl09